Been using TW for a while now, also never had any issues with gaming. Following the instructions already given in other comments.

Install proton-up flatpak, install steam,lutris/heroic, whatever you want to use for the other stores. That has worked for me on any distro.

Try open-RGB for RGB control.

Your hardware isn’t bleeding edge, so older packages aren’t really that much of an issue unless you suffer from FOMO or just have to have that 1.1.2 feature, which case I found Flatpak delivers a fair amount of up-to-date apps.

The LCD display might need a Windows VM just to jump into when you want to manage that or look into opencorsairlink: https://github.com/audiohacked/OpenCorsairLink

Gkraken: https://gitlab.com/leinardi/gkraken/blob/master/README.md

Secure Boot is definitely possible with oS TW. You can select to enable it on install.

With AMD you will be using the open-source drivers for gaming which means openSUSE will give you the benefit of the latest and greatest drivers for best performance.

Honestly just install it with your DE of choice and install Steam. Even for non-Steam games I find that loading them through Steam to use Proton is typically better than setting up Wine independently.

I would say, when playing games, if you get audio crackling, try a different kernel such as Liquorix (https://software.opensuse.org//download.html?project=home%3Ahwsnemo%3Akernels&package=kernel-liquorix). I’ve had that issue on my hardware across multiple distros, and this kernel solves it.

I believe it’s something with a kernel parameter regarding scheduling, specifically as noted in this features list (https://liquorix.net/#features)

High Resolution Scheduling: 1000hz tick rate for precise low jitter task scheduling.

You may or may not get this issue with your hardware, but if you do, then this is something you could try.

Otherwise, great distro, I’m currently on it.