

You have enough failures on each disk to make me suspect an issue with the usb-connected drive bay. I ran into similar issues with a cheap pci-e sata adapter, where little hiccups and latency in the communication layer would cause zfs to take disks offline randomly. Read, write, and checksum errors would slowly accumulate across all of the disks. Switched that machine to a proper enterprise hba, the issues vanished, and the disks are all healthy 3-4 years later.

https://wiki.archlinux.org/title/Modprobed-db can create a profile of the kernel modules that get loaded by your system over time. You can feed that directly into
make localmodconfigto build a kernel that only includes those modules, or use the data to build a modprobe whitelist.